Polymorphisms suggest mitochondrial recombination

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Recombination of human mitochondrial DNA.

Human mitochondrial DNA (mtDNA) is a 16.5-kb, circular genome essential for the maintenance of mitochondrial function and is present in multiple copies in most cell types. High sequence divergence and maternal inheritance make mtDNA useful in tracing human lineages. Whether recombination occurs between mitochondrial genomes is a longstanding question in mitochondrial biology, human evolution, a...

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Animal mitochondrial DNA recombination revisited

Exchange of homologous sequences between mitochondrial DNA (mtDNA) molecules is thought to be absent in animals, primarily because of a failure to observe clear cases of recombinant haplotypes in natural populations. However, whether mtDNA recombination occurs is a different issue from whether it produces new haplotypes. A requirement for the latter is heteroplasmy – the presence of more than o...

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Recombination in human mitochondrial DNA?

The possibility of recombination in human mitochondrial DNA (mtDNA) has been hotly debated over the last few years. In this study, a general model of recombination in circular molecules is developed and applied to a recently published African sample (n = 21) of complete mtDNA sequences. It is shown that the power of correlation measures to detect recombination in circular molecules can be vanis...

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ژورنال

عنوان ژورنال: Genome Biology

سال: 2000

ISSN: 1474-760X

DOI: 10.1186/gb-2000-1-1-reports014